International Journal of Cardiovascular Research & Innovation

ABSTRACT

Coronary artery blockages that restrict blood flow to the heart are the main cause of ischemic heart disease (IHD), the world's largest cause of death. Traditional treatments are ineffective at repairing damaged cardiac tissue; instead, they concentrate on managing symptoms. In cardiovascular therapy, exosomes produced from induced pluripotent stem cells (iPSCs) have lately become a safer option since they provide regenerative advantages without the concerns of tumor growth or immune rejection that come with whole-cell therapies. iPSCs release these nanosized vesicles, which contain bioactive compounds with pro-angiogenic, anti-inflammatory, and anti-apoptotic qualities that aid in tissue repair and enhance cardiac function. Preclinical research demonstrates that exosomes produced from iPSCs promote heart regeneration by increasing angiogenesis, decreasing fibrosis, and improving myocardial cell survival. This mini-review addresses the cardioprotective mechanisms and therapeutic prospects of iPSC-derived exosomes in treating IHD. Research on exosomes may pave the way for improved cardiovascular regenerative therapy.

Article History

KEYWORDS

1. Induced pluripotent stem cells
2. Exosomes
3. Myocardial ischemia
4. Coronary vessels
5. Cell survival
6. Neoplasms