International Journal of Cardiovascular Research & Innovation

ABSTRACT

Herbal background: Cardiac remodeling is a progressive structural and functional alteration of the heart often resulting from chronic hypertension or myocardial stress. Early identification of this process remains a clinical challenge, as conventional methods may not detect subtle molecular or anatomical changes in asymptomatic individuals.

Case summary: We report the case of a 29-year-old male patient with a recent diagnosis of mild hypertension who presented with nonspecific symptoms such as fatigue and occasional palpitations. While initial electrocardiography and basic echocardiographic assessments appeared unremarkable, advanced investigations revealed elevated levels of circulating biomarkers including NT-proBNP and Galectin-3. Further molecular profiling showed upregulation of extracellular matrix-related genes. Cardiac MRI identified early signs of left ventricular hypertrophy, confirming the onset of cardiac remodeling. Prompt initiation of pharmacological therapy and lifestyle modifications led to stabilization of biomarker levels and clinical improvement over a three-month follow-up period.

Conclusion: This case highlights the critical role of biomolecular diagnostics and advanced imaging in the early detection of cardiac remodeling, particularly in young patients with minimal symptoms. Incorporating biotechnological tools into routine cardiovascular screening may enable timely intervention and improved long-term outcomes.

Article History

Received 09 January 2025; Revised 23 January 2025; Accepted 30 January 2025

KEYWORDS

1. Cardiac remodeling
2. Biomolecular markers
3. Hypertension
4. Cardiac MRI
5. NT-proBNP
6. Galectin-3