International Journal of Cardiovascular Research & Innovation

ABSTRACT

Endothelial dysfunction is progressively acknowledged as a vital pathophysiological occurrence in the onset of cardiovascular diseases (CVD) and other chronic ailments. It is marked by a dysfunction in the endothelium's capacity to sustain vascular homeostasis, resulting in modified vascular tone, heightened inflammation, and conditions favorable to thrombosis. Endothelial cells that coat the blood vessels are crucial in managing vascular function, and their dysfunction can be caused by various risk factors including hypertension, hyperlipidemia, smoking, diabetes, and obesity. This article examines the processes that contribute to endothelial dysfunction, its involvement in the development of cardiovascular disease, and its connection to other illnesses. Additionally, it explores possible therapeutic approaches focused on reestablishing endothelial function, emphasizing lifestyle changes, medication options, and new treatment methods.

Article History

Received 6 February 2025; Revised 21 February 2025; Accepted 28 February 2025

KEYWORDS

1. Endothelial dysfunction
2. Cardiovascular disease
3. Hyperglycemia
4. Risk factors
5. Therapeutic strategies